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S., Arutjunyan, A

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Tryptamine produced by bacterial decarboxylation of dietary tryptophan accelerates gastrointestinal transit by activating the epithelial G-protein-coupled receptor (GPCR) serotonin receptor-4 (5-HT 4 R) and increasing anion-dependent fluid secretion in the proximal colon (Bhattarai et al., 2018)

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Multiple residues in DET1 form hydrogen bonds and electrostatic interactions with Ube2e2, including DET1 D289 : Ube2e2 R126 , DET1 H297 : Ube2e2 T201 , DET1 D324 : Ube2e2 R88 and Ube2e2 R124 , DET1 R317 : Ube2e2 T68 (Fig